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 <!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.0 20120330//EN" "http://jats.nlm.nih.gov/publishing/1.0/JATS-journalpublishing1.dtd"> <article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" article-type="in-brief" dtd-version="1.0" xml:lang="en">
  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">JCDP</journal-id>
      <journal-title-group>
        <journal-title>Journal of Clinical and Diagnostic Pathology</journal-title>
      </journal-title-group>
      <issn pub-type="epub">2689-5773</issn>
      <publisher>
        <publisher-name>Open Access Pub</publisher-name>
        <publisher-loc>United States</publisher-loc>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">JCDP-21-3890</article-id>
      <article-id pub-id-type="doi">10.14302/issn.2689-5773.jcdp-21-3890</article-id>
      <article-categories>
        <subj-group>
          <subject>in-brief</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Solitary Splenic Hydatid Cyst</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <name>
            <surname>Zakaria</surname>
            <given-names>MERAD</given-names>
          </name>
          <xref ref-type="aff" rid="idm1842739100">1</xref>
          <xref ref-type="aff" rid="idm1842737732">*</xref>
        </contrib>
      </contrib-group>
      <aff id="idm1842739100">
        <label>1</label>
        <addr-line>Department of pathological anatomy and cytology, Hospital Center of Sidi Bel Abbes, Faculty of Medecine, Djilali Liabes University,  22000, ALGERIA.</addr-line>
      </aff>
      <aff id="idm1842737732">
        <label>*</label>
        <addr-line>Corresponding Author</addr-line>
      </aff>
      <contrib-group>
        <contrib contrib-type="editor">
          <name>
            <surname>Qiping</surname>
            <given-names>Dong</given-names>
          </name>
          <xref ref-type="aff" rid="idm1842855732">1</xref>
        </contrib>
      </contrib-group>
      <aff id="idm1842855732">
        <label>1</label>
        <addr-line>China.</addr-line>
      </aff>
      <author-notes>
        <corresp>Corresponding author: Zakaria MERAD, Department of Pathological Anatomy and Cytology, Hospital Center of Sidi Bel Abbes; Faculty of Medicine, Djilali Liabes University, 22000, Algeria. Email: <email>zmerad79@yahoo.fr</email></corresp>
        <fn fn-type="conflict" id="idm1842333868">
          <p>The authors have declared that no competing interests exist.</p>
        </fn>
      </author-notes>
      <pub-date pub-type="epub" iso-8601-date="2021-08-02">
        <day>02</day>
        <month>08</month>
        <year>2021</year>
      </pub-date>
      <volume>1</volume>
      <issue>4</issue>
      <fpage>1</fpage>
      <lpage>4</lpage>
      <history>
        <date date-type="received">
          <day>02</day>
          <month>07</month>
          <year>2021</year>
        </date>
        <date date-type="accepted">
          <day>22</day>
          <month>07</month>
          <year>2021</year>
        </date>
        <date date-type="online">
          <day>02</day>
          <month>08</month>
          <year>2021</year>
        </date>
      </history>
      <permissions>
        <copyright-statement>© </copyright-statement>
        <copyright-year>2021</copyright-year>
        <copyright-holder>Zakaria MERAD</copyright-holder>
        <license xlink:href="http://creativecommons.org/licenses/by/4.0/" xlink:type="simple">
          <license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</license-p>
        </license>
      </permissions>
      <self-uri xlink:href="http://openaccesspub.org//jcdp/article/1673">This article is available from http://openaccesspub.org//jcdp/article/1673</self-uri>
      <abstract>
        <p>Splenic hydatid cyst is very rare, caused by the parasite echinococcus granulosus. Humans are                          considered an accidental intermediate host in the                      development of the parasite cycle. It poses a diagnostic dilemma with other cystic masses despite improved medical imaging techniques often requiring                             exploratory surgeries for fear of missing out on a                  malignant tumor. Total or partial splenectomy remains the treatment of first choice and the most effective. We report a case of solitary splenic hydatid cyst and discuss the different differential diagnoses and                     therapeutic modalities.</p>
      </abstract>
      <kwd-group>
        <kwd>Macroscopic</kwd>
        <kwd>hydatid</kwd>
        <kwd>cyst</kwd>
        <kwd>echinococcus granulosus</kwd>
        <kwd>spleen</kwd>
      </kwd-group>
      <counts>
        <fig-count count="0"/>
        <table-count count="0"/>
        <page-count count="2"/>
      </counts>
    </article-meta>
  </front>
  <body>
    <sec id="idm1842605708" sec-type="intro">
      <title>Introduction</title>
      <p>Splenic hydatid cyst is a parasitosis caused by the development of the larvae of echinococcosis granulosis, it is very rare with annual incidence                between 0.5% and 4%. <xref ref-type="bibr" rid="ridm1842055004">1</xref><xref ref-type="bibr" rid="ridm1842119300">2</xref> Humans are an                       accidental intermediate host and become infected by eating raw food contaminated by the parasite <xref ref-type="bibr" rid="ridm1842152276">3</xref>. The hydatid cyst is usually discovered incidentally by a mass in the left hypochondrium, sometimes with complications such as constipation, dyspnea or even dysphagia<xref ref-type="bibr" rid="ridm1841906100">4</xref>. The mechanism of splenic                   involvement is poorly understood, probably via the arterial route <xref ref-type="bibr" rid="ridm1841902068">5</xref>. The treatment is surgical without forgetting to take precautions to avoid the                            dissemination of scolices <xref ref-type="bibr" rid="ridm1841892948">6</xref>.</p>
    </sec>
    <sec id="idm1842604268" sec-type="cases">
      <title>Case Report</title>
      <p> It was a 50-year-old man, living in the                      companion with the notion of contact with animals, especially sheep, with no particular history admitted to the emergency for malaise associated with a                  deterioration of the general condition with nausea and vomiting (weight 45 kg). On admission, the      patient was afebrile (36.8 °), eupneic (23 cycles / min, 95%               oxygen saturation), tachycardium at 120 beats / min with a blood pressure of 130/85. His wife mentioned that the mass had started to overgrow over the last seven months. Physical examination found abdominal asymmetry and a mass in the left hypochondrium. Abdominal ultrasound revealed a thin-walled, unilocular cystic formation with calcification, occupying almost the entire spleen,                    measuring 12 cm in the antero-posterior axis. The                         biological assessment showed hypereosinophilia. The hydatid serology (direct haemagglutination) was positive (1/300). The abdominal scanner revealed a fluid                        collection occupying the entire spleen, the wall of which was discreetly enhanced after injection of contrast                      product measured 15cm / 12cm. There was no                           involvement of liver or other organs. A total splenectomy was performed urgently for the compression of                         neighboring organs. Macroscopic study found a part of total splenectomy measuring 20 / 15cm (<xref ref-type="fig" rid="idm1843157532">figure 1</xref>) with at the opening the presence of a cystic formation occupying the entire spleen containing whitish membranes and              numerous vesicles (<xref ref-type="fig" rid="idm1843157604">figure 2</xref>) and the histological                   examination concluded to a hydatid splenic cyst. The postoperative course was straightforward and the patient was discharged on the eighth day with  medical treatment based on albendazole for three months.</p>
      <fig id="idm1843157532">
        <label>Figure 1.</label>
        <caption>
          <title> Macroscopic appearance of a splenic hydatid cyst.</title>
        </caption>
        <graphic xlink:href="images/image1.jpg" mime-subtype="jpg"/>
      </fig>
      <fig id="idm1843157604">
        <label>Figure 2.</label>
        <caption>
          <title> Shows cut section macroscopic of splenic hydatid cyst in centre there is hydatid membranes white.</title>
        </caption>
        <graphic xlink:href="images/image2.jpg" mime-subtype="jpg"/>
      </fig>
    </sec>
    <sec id="idm1842602396" sec-type="discussion">
      <title>Discussion</title>
      <p>The hydatid cyst (echinococcus granulosus)          constitutes a major public health problem in endemic regions especially Africa, Asis, Latin America and                 Australia where their main activities are cattle breeding. Splenic hydatid cyst is very rare with an annual incidence between 0.5% and 4% <xref ref-type="bibr" rid="ridm1842055004">1</xref><xref ref-type="bibr" rid="ridm1842119300">2</xref>. The most common sites of hydatid disease are the liver (60–70%), which acts as a first filter and the lungs (10–40%), which acts assecond filter. The rare sites include spleen, thyroid, gall bladder, central nervous system, kidney, psoas sheet,                             retroperitoneal region, orbit. Practically any organ can be infested by hydatid disease <xref ref-type="bibr" rid="ridm1841906100">4</xref>.</p>
      <p>The parasite's life cycle requires two hosts, the fox or dog which is the major definitive host and the                   rodents which are intermediate hosts. Man is an                          accidental intermediate host, becomes contaminated by eating raw vegetables contaminated by the faeces of                  infected carnivores or directly by touching these animals and this is the occasion of immunosuppression following an inflammatory or viral or bacterial disease. that hydatid disease is discovered <xref ref-type="bibr" rid="ridm1842152276">3</xref><xref ref-type="bibr" rid="ridm1841906100">4</xref>.</p>
      <p>The mechanism of splenic involvement is poorly understood. Arterial dissemination of an echinococcosis granulosus embryo that has passed hepatic and                    pulmonary filters seems the most likely theory <xref ref-type="bibr" rid="ridm1841902068">5</xref>.</p>
      <p>Berlot is the first to describe the splenic hydatid cyst discovered on autopsy in 1790 <xref ref-type="bibr" rid="ridm1841906100">4</xref> therefore the               circumstances of discovery are variable and depend on the evolutionary stage of the disease, echinococcosis granulosus can be manifested by atypical pain in the left hypochondrium and nonspecific, low back pain or by a palpable mass, sometimes complications such as                       tachycardia, dyspnea, deterioration of the general                           condition (in our case) or even dysphagia when the                volume of the cyst is large <xref ref-type="bibr" rid="ridm1841892948">6</xref>.</p>
      <p>In practice, the biological examinations are                   normal except for a slight eosinophilia, the serological tests proposed for the diagnosis of echinococcosis         granulosus are first, the sensitive Elisa test, if it is                  positive, it must be followed by a another test that of Western-Bloot to confirm the diagnosis <xref ref-type="bibr" rid="ridm1841875116">7</xref><xref ref-type="bibr" rid="ridm1841878428">8</xref>.</p>
      <p>Ultrasound and computed tomography CT play an important role in the diagnosis of echinococcosis            granulosus allowing to better specify the site and the     relationships with neighboring organs, the most                       frequently found appearance is that of a cystic mass with a wall thin with sometimes an appearance of detachment of membranes or the presence of daughter                               vesicles <xref ref-type="bibr" rid="ridm1841906100">4</xref><xref ref-type="bibr" rid="ridm1841902068">5</xref><xref ref-type="bibr" rid="ridm1841892948">6</xref>.</p>
      <p>Splenic hydatid cyst poses a diagnostic dilemma for             clinicians with many pathologies such as angiosarcoma in its cystic form, lymphangioma, epidermal cyst and                    dermaid <xref ref-type="bibr" rid="ridm1842119300">2</xref><xref ref-type="bibr" rid="ridm1842152276">3</xref><xref ref-type="bibr" rid="ridm1841892948">6</xref><xref ref-type="bibr" rid="ridm1841878428">8</xref><xref ref-type="bibr" rid="ridm1841876844">9</xref>. The main complication is the rupture of the cyst leading to death from anaphylactic                        shock <xref ref-type="bibr" rid="ridm1842055004">1</xref><xref ref-type="bibr" rid="ridm1841906100">4</xref><xref ref-type="bibr" rid="ridm1841892948">6</xref><xref ref-type="bibr" rid="ridm1841857260">10</xref>.</p>
      <p>The puncture aspiration of the liquid remains a very delicate intervention because of the risk of the                         passage of the parasites in the blood circulation but the standard treatment is total or partial splenectomy                  followed by medical treatment based on                                           albendazole <xref ref-type="bibr" rid="ridm1841892948">6</xref><xref ref-type="bibr" rid="ridm1841875116">7</xref><xref ref-type="bibr" rid="ridm1841876844">9</xref><xref ref-type="bibr" rid="ridm1841857260">10</xref>.</p>
    </sec>
    <sec id="idm1842601604" sec-type="conclusions">
      <title>Conclusion </title>
      <p>Splenic hydatid cyst is very rare, posing a real diagnostic dilemma with other cystic masses. However, the diagnosis of certainty remains the prerogative of the anatomo-pathological examination, especially since                       effective treatment remains on the prevention of this    hydatid disease .</p>
    </sec>
  </body>
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