<?xml version="1.0" encoding="utf8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.0 20120330//EN" "http://jats.nlm.nih.gov/publishing/1.0/JATS-journalpublishing1.dtd">
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" article-type="research-article " dtd-version="1.0" xml:lang="en">
  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">JSLR</journal-id>
      <journal-title-group>
        <journal-title>Journal of Spleen And Liver Research</journal-title>
      </journal-title-group>
      <issn pub-type="epub">2578-2371</issn>
      <publisher>
        <publisher-name>Open Access Pub</publisher-name>
        <publisher-loc>United States</publisher-loc>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">JSLR-24-5157</article-id>
      <article-id pub-id-type="doi">10.14302/issn.2578-2371.jslr-24-5157</article-id>
      <article-categories>
        <subj-group>
          <subject>research-article</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Splenectomy Reports</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <name>
            <surname>Günay</surname>
            <given-names>Uluc</given-names>
          </name>
          <xref ref-type="aff" rid="idm1842411836">1</xref>
          <xref ref-type="aff" rid="idm1842410684">*</xref>
        </contrib>
      </contrib-group>
      <aff id="idm1842411836">
        <label>1</label>
        <addr-line>General Surgeon</addr-line>
      </aff>
      <aff id="idm1842410684">
        <label>*</label>
        <addr-line>Corresponding Author </addr-line>
      </aff>
      <author-notes>
        <corresp>Corresponding author: Günay Uluc, General Surgeon. Email: <email>gunayzb@gmail.com</email></corresp>
        <fn fn-type="conflict" id="idm1841612524">
          <p>There is no conflict of interest.</p>
        </fn>
      </author-notes>
      <pub-date pub-type="epub" iso-8601-date="2024-08-24">
        <day>24</day>
        <month>08</month>
        <year>2024</year>
      </pub-date>
      <volume>1</volume>
      <issue>4</issue>
      <fpage>17</fpage>
      <lpage>22</lpage>
      <history>
        <date date-type="received">
          <day>17</day>
          <month>06</month>
          <year>2024</year>
        </date>
        <date date-type="accepted">
          <day>31</day>
          <month>07</month>
          <year>2024</year>
        </date>
        <date date-type="online">
          <day>24</day>
          <month>08</month>
          <year>2024</year>
        </date>
      </history>
      <permissions>
        <copyright-statement>© </copyright-statement>
        <copyright-year>2024</copyright-year>
        <copyright-holder>Günay Uluc</copyright-holder>
        <license xlink:href="http://creativecommons.org/licenses/by/4.0/" xlink:type="simple">
          <license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</license-p>
        </license>
      </permissions>
      <self-uri xlink:href="http://openaccesspub.org/jslr/article/2152">This article is available from http://openaccesspub.org/jslr/article/2152</self-uri>
      <abstract>
        <sec id="idm1842274780">
          <title>Introduction</title>
          <p>It was seen that splenectomy creates a disability situation in an individual, and in order to eliminate it, people applied to health boards to get a report to eliminate their social and economic losses recognized to them.</p>
        </sec>
        <sec id="idm1842274564">
          <title>Objective</title>
          <p>To examine the reason for surgery, method of surgery and the type of report they wanted to receive in splenectomised patients who applied to the general surgery committee polyclinic in 2017-2018-2019-2020 and 2023 when the pandemic ended.</p>
        </sec>
        <sec id="idm1842275860">
          <title>Materials and Methods</title>
          <p>Patients who applied to general surgery outpatient clinics were asked whether they had any surgery related to general surgery, and epicrises and pathology results of splenectomised patients were seen and recorded.</p>
        </sec>
        <sec id="idm1842276220">
          <title>Results</title>
          <p>Of the 23 splenectomised patients, 15 were female and 8 were male. Of the 15 female patients, 3 were splenectomised for ovarian ca, 3 for gastric ca, 2 for distal pancreatic ca, 2 for lymphoma, 1 for colon ca, 1 for traumatic cause, 2 for ITP, 1 for sarcoidosis. In male patients, 4 were splenectomised for traumatic, 1 for colon ca, 1 for ITP, 1 for thalassemia major and 1 for CML. The mean age of female patients was 48.1 years and the mean age of male patients was 37.4 years. The most common reason for splenectomy in women was malignancy and the most common reason for splenectomy in men was trauma.</p>
        </sec>
        <sec id="idm1842275284">
          <title>Conclusion</title>
          <p>Splenectomized patients had applied to receive the most DSR.</p>
        </sec>
      </abstract>
      <kwd-group>
        <kwd>Splenectomy</kwd>
        <kwd>Postsplenectomy</kwd>
        <kwd>Report type</kwd>
      </kwd-group>
      <counts>
        <fig-count count="0"/>
        <table-count count="6"/>
        <page-count count="6"/>
      </counts>
    </article-meta>
  </front>
  <body>
    <sec id="idm1842272908">
      <title>Objective</title>
      <p>To examine the reason for surgery, the method of surgery and the type of report they wanted to receive in splenectomised patients who applied to the general surgery committee polyclinic in 2017-2018- 2019- 2020 and in 2023 when the pandemic ended.</p>
    </sec>
    <sec id="idm1842273916" sec-type="materials">
      <title>Materials and Methods</title>
      <p>Patients who applied to general surgery outpatient clinics were asked whether they had any surgery related to general surgery, and epicrises and pathology results of splenectomised patients were seen and recorded. Abdominal ultrasounds and abdominal tomographs of some patients with splenectomized cases were also recorded.Oncological documents of some patients who were splenectomized due to malignancy were examined</p>
    </sec>
    <sec id="idm1842273844" sec-type="results">
      <title>Results</title>
      <p>Of the 23 splenectomised patients, 15 were female and 8 were male. Of the 15 female patients, 3 were splenectomised for ovarian ca, 3 for gastric ca, 2 for distal pancreatic ca, 1 for colon ca, 1 for traumatic cause, 2 for lymphoma, 2 for ITP, 1 for sarcoidosis. In 8 male patients, 4 were splenectomised for traumatic, 1 for colon ca, 1 for ITP, 1 for CML (chronic myelocytic leukaemia) and 1 for thalassaemia major. The mean age of female patients was 48.1 years and the mean age of male patients was 37:4 years. The most common reason for splenectomy in women was malignancy and the most common reason for splenectomy in men was trauma (<xref ref-type="table" rid="idm1849187412">Table 1</xref>). </p>
      <table-wrap id="idm1849187412">
        <label>Table 1.</label>
        <caption>
          <title> Reasons for splenectomy in 15 female patients</title>
        </caption>
        <table rules="all" frame="box">
          <tbody>
            <tr>
              <td> </td>
              <td>
                <bold>n</bold>
              </td>
              <td>
                <bold>(%)</bold>
              </td>
            </tr>
            <tr>
              <td>Stomach cancer </td>
              <td>3</td>
              <td>(%20)</td>
            </tr>
            <tr>
              <td>Over cancer </td>
              <td>3</td>
              <td>(%20)</td>
            </tr>
            <tr>
              <td>Distal pancreatic ca </td>
              <td>2</td>
              <td>(%13,3)</td>
            </tr>
            <tr>
              <td>Colon cancer </td>
              <td>1</td>
              <td>(%6,6)</td>
            </tr>
            <tr>
              <td>ITP </td>
              <td>2</td>
              <td>(%13,3)</td>
            </tr>
            <tr>
              <td>Lymphoma</td>
              <td>2</td>
              <td>(%13,3)</td>
            </tr>
            <tr>
              <td>Traumatic </td>
              <td>1</td>
              <td>(%6,6)</td>
            </tr>
            <tr>
              <td>Sarcoidosis</td>
              <td>1</td>
              <td>(%6,6)</td>
            </tr>
          </tbody>
        </table>
      </table-wrap>
      <p>Of the 8 male patients, 4 were traumatic, 1 had colon ca, 1 had ITP, 1 had CML (chronic myelocytic leukaemia) and 1 had splenectomy for thalassaemia major. (<xref ref-type="table" rid="idm1849123204">Table 2</xref>).</p>
      <table-wrap id="idm1849123204">
        <label>Table 2.</label>
        <caption>
          <title> Reasons for splenectomy in 7 male patients</title>
        </caption>
        <table rules="all" frame="box">
          <tbody>
            <tr>
              <td> </td>
              <td>
                <bold>n</bold>
              </td>
              <td>
                <bold>(%)</bold>
              </td>
            </tr>
            <tr>
              <td>Traumatic </td>
              <td>4</td>
              <td>(%50)</td>
            </tr>
            <tr>
              <td>Colon Ca</td>
              <td>1</td>
              <td>(%12,5)</td>
            </tr>
            <tr>
              <td>ITP</td>
              <td>1</td>
              <td>(%12,5)</td>
            </tr>
            <tr>
              <td>Thalassaemia Major</td>
              <td>1</td>
              <td>(%12,5)</td>
            </tr>
            <tr>
              <td>CML</td>
              <td>1</td>
              <td>(%12,5)</td>
            </tr>
          </tbody>
        </table>
      </table-wrap>
      <p>The mean age of female patients was 48.1 years and the mean age of male patients was 37.4 years.</p>
      <sec id="idm1842204156">
        <title>Comorbidities</title>
        <p>Hypertension in 2 patients, diabetes mellitus in 1 patient,  hyperlipidemia in 1 patient,  asthma in 1 patient, hepatitis B in 1 patient, osteoporosis in 1 patient, thyroid papillary ca in 1 patient.</p>
        <p>Of the 15 female patients, 11 had applied for a disability status report, 2 for exemption from special consumption tax, 1 for disability retirement, and 1 for a guardian appointment report. (<xref ref-type="table" rid="idm1849098828">Table 3</xref>) </p>
        <table-wrap id="idm1849098828">
          <label>Table 3.</label>
          <caption>
            <title> Report types of 15 female patients</title>
          </caption>
          <table rules="all" frame="box">
            <tbody>
              <tr>
                <td> </td>
                <td>
                  <bold>n</bold>
                </td>
                <td>
                  <bold>(%)</bold>
                </td>
              </tr>
              <tr>
                <td>DSR (Disability Status Report)</td>
                <td>11</td>
                <td>(%73,3)</td>
              </tr>
              <tr>
                <td>Disability Retirement</td>
                <td>1</td>
                <td>(% 6,7)</td>
              </tr>
              <tr>
                <td>SCT (Special Consumption Tax)</td>
                <td>2</td>
                <td>(%13,3)</td>
              </tr>
              <tr>
                <td>Appointing a guardian</td>
                <td>1</td>
                <td>(% 6,7)</td>
              </tr>
            </tbody>
          </table>
        </table-wrap>
        <p>The types of reports received by the 8 male patients were as follows: 6 disability reports, 1 military exemption report, 1 private security officer report (<xref ref-type="table" rid="idm1849070484">Table 4</xref>).</p>
        <table-wrap id="idm1849070484">
          <label>Table 4.</label>
          <caption>
            <title> Types of reports received by a total of 8 male patients</title>
          </caption>
          <table rules="all" frame="box">
            <tbody>
              <tr>
                <td> </td>
                <td>
                  <bold>n </bold>
                </td>
                <td>
                  <bold>(%)</bold>
                </td>
              </tr>
              <tr>
                <td>DSR ( Disability Status Report)</td>
                <td>6</td>
                <td>(%75)</td>
              </tr>
              <tr>
                <td>Exemption from military service</td>
                <td>1</td>
                <td>(%12,5)</td>
              </tr>
              <tr>
                <td>Being a private security</td>
                <td>1</td>
                <td>(%12,5)</td>
              </tr>
            </tbody>
          </table>
        </table-wrap>
        <p>Of the 23 patients with splenectomy, 22 patients had conventional splenectomy and 1 patient had laparoscopic splenectomy.(<xref ref-type="table" rid="idm1849054428">Table 5</xref>) </p>
        <table-wrap id="idm1849054428">
          <label>Table 5.</label>
          <caption>
            <title> Splenectomy methods</title>
          </caption>
          <table rules="all" frame="box">
            <tbody>
              <tr>
                <td> </td>
                <td>
                  <bold>n </bold>
                </td>
                <td>
                  <bold>(%)</bold>
                </td>
              </tr>
              <tr>
                <td>Conventional splenectomy</td>
                <td>22</td>
                <td>(%95,6)</td>
              </tr>
              <tr>
                <td>Laparoscopic splenectomy</td>
                <td>1</td>
                <td>(% 4,4)</td>
              </tr>
            </tbody>
          </table>
        </table-wrap>
      </sec>
    </sec>
    <sec id="idm1842159476" sec-type="discussion">
      <title>Discussion</title>
      <sec id="idm1842160628">
        <title>Objective and Introduction</title>
        <p>Spleen is an organ with immunological functions. T and B lymphocytes in the spleen produce antibody response against antigen and thus create immune response. Macrophages in the spleen remove pathological erythrocytes, leukocytes, platelets, especially encapsulated pneumococci from the circulation, the spleen stores erythrocytes, reticulocytes, platelets, lymphocytes ready for circulation, contains 11% of the normal volume of plasma, and is the storage place for re-use of haemoglobin iron <xref ref-type="bibr" rid="ridm1842247220">1</xref>. When antigen is encountered in the spleen, ig M, ig G opsonised antibody response is generated from the white pulp, tuftsin and properdini and encapsulated bacteria that are not sufficiently opsonised phagocytose pneumococci and h.influenza, but when the spleen is removed, this phagocytosis does not occur and the risk of postplenectomy sepsis arises<xref ref-type="bibr" rid="ridm1842250388">2</xref>. Splenectomy is one of the causes of essential thrombocytosis and may lead to myelofibrosis and myelosuppression may be required; therefore, low dose aspirin treatment is recommended to prevent microvascular thrombosis in essential thrombocytosis. Patients applied for a health board report due to deficiencies and complications related to the loss of function after the loss of such an important organ, ongoing haematological disease; ITP, beta thalassaemia, or cancer-related problems, and socioeconomic loss. Splenectomy was performed for haematological disease, adjacent organ malignancies, metastatic splenic tumour, traumatic reason in this study. ITP is a disease with a rate of 5-10 per 100.000 and is frequently observed in women aged 15-50 years  <xref ref-type="bibr" rid="ridm1842258820">4</xref>.  Splenectomy is an intervention that provides remission in patients with Immune (idiopathic) Thrombocytopenic Purpura who do not improve with medical treatment. ITP is an entity characterised by shortening of platelet lifespan due to immunoglobulin G-type antiplatelet factors, thus decrease in the amount of platelets and proliferation of megakaryocytes in the bone marrow. Thrombocytopenia improves to normal levels in 70-80% with splenectomy <xref ref-type="bibr" rid="ridm1842104676">5</xref>.</p>
        <p>Thalassemia originates from a single gene defect, is a hereditary haemoglobin production anomaly and is mostly autosomal recessive <xref ref-type="bibr" rid="ridm1842250388">2</xref><xref ref-type="bibr" rid="ridm1842110004">6</xref>. In thalassemia, hypochromic microcytic anaemia is present and it is aimed to increase the haemoglobin level above 9ml/dl with erythrocyte transfusions <xref ref-type="bibr" rid="ridm1842250388">2</xref>. Splenectomy is performed in the presence of splenomegaly and splenic infarction and does not correct the genetic defect but reduces the need for blood transfusion <xref ref-type="bibr" rid="ridm1842250388">2</xref>. Autologous genetic therapies are being studied in thalassemias <xref ref-type="bibr" rid="ridm1842107700">7</xref>.</p>
        <p>In a study in which 204 splenectomy cases were analysed, cases performed for haematological reasons ranked first with 58 cases and 38 splenectomies due to traumatic reasons ranked second, and the increase in conservative approaches after posttraumatic splenic injury was effective in this <xref ref-type="bibr" rid="ridm1842096068">8</xref>.</p>
        <p>In another study including 184 splenectomy cases, it was observed that 54 cases were performed  for haematological  reasons  and 70.4%  of  these  54 splenectomies were  </p>
        <p>ITP cases <xref ref-type="bibr" rid="ridm1842093044">9</xref>. The  most  common  reason for splenectomy  in  chronic  myeloid  leukemia  was  splenomegaly  and  platelet  deficiency<xref ref-type="bibr" rid="ridm1842084596">10</xref><xref ref-type="bibr" rid="ridm1842083660">11</xref>.</p>
        <p>Post-splenectomy sepsis cases, which are seen at a rate of 0.1-0.5% after splenectomy and generally less than 1%, reveal the importance of the function of the organ . In the USA, 25000 splenectomies are performed annually due to trauma, haematological reasons and cancer, pneumococcal, meningococcal and influenza vaccines are administered to asplenic individuals to protect them from postplenectomy sepsis, and the rate of OPSI (overhelming postsplenectomy infectıon) is 3-5% (12). By preserving 25% of the splenic parenchyma with laparoscopic partial splenectomy, the spleen can fulfil its immune function and the risk of thromboembolism can be reduced <xref ref-type="bibr" rid="ridm1842069228">13</xref><xref ref-type="bibr" rid="ridm1842066708">14</xref>.</p>
        <p>In this study, it was observed that in female patients who applied for a disability report after the loss of an important haematopoietic organ, patients who underwent splenectomy due to general surgery and gynaecological malignancies were in the first place, and splenectomies due to ITP were in the second place. Traumatic splenectomies ranked first and haematological splenectomies ranked second in the applications made by male patients to obtain a disability report due to splenectomy. It was observed that female patients were more common in applications according to gender.</p>
        <p>In this study in which splenectomised cases were examined, patient epicrises were found to be sufficient as a document, and only one patient who applied for a medical board report with the request to be exempt from military service was decided to be exempt from military service in accordance with article 45/B-13 of the military service regulation in the committee with the receipt of a radiology report with splenectomised case evaluation <xref ref-type="bibr" rid="ridm1842061812">15</xref>.</p>
        <p>Splenectomised patients who applied to the medical board were evaluated in terms of functional deficiencies caused by organ loss, and all patients were given 10 points as a percentage score for disability only because of absence of spleen, and additional points were added for accompanying malignancies related to general surgery (<xref ref-type="table" rid="idm1849032156">Table 6</xref>).</p>
        <table-wrap id="idm1849032156">
          <label>Table 6.</label>
          <caption>
            <title> Scoring of splenectomised cases</title>
          </caption>
          <table rules="all" frame="box">
            <tbody>
              <tr>
                <td> </td>
                <td>
                  <bold>(%)</bold>
                </td>
              </tr>
              <tr>
                <td>Splenectomy only</td>
                <td>10</td>
              </tr>
              <tr>
                <td>Splenectomy and gastric ca</td>
                <td>10% + 25%</td>
              </tr>
              <tr>
                <td>Splenectomy and colon ca</td>
                <td>10% + 25%</td>
              </tr>
              <tr>
                <td>Splenectomy and pancreatic ca</td>
                <td>10% + 25%</td>
              </tr>
            </tbody>
          </table>
        </table-wrap>
      </sec>
    </sec>
    <sec id="idm1842163436" sec-type="conclusions">
      <title>Conclusion</title>
      <p>It was observed that the highest number of applications for obtaining a report was made for the report declaring the status of disability, which includes the rights to benefit from tax deductions, to receive a disability salary, and to obtain a disabled identity card.</p>
    </sec>
    <sec id="idm1842163724">
      <title>Financial support</title>
      <p>There is no financial support. </p>
    </sec>
    <sec id="idm1842164444">
      <title>Ethical approval statement</title>
      <p>The research project, was approved four April 12 th 2023 by Clinical Researches Ethics Committee of S.B.İstanbul Medeniyet University Göztepe Research and Training Hospital. The approval number is 2023/250.This study was a retrospective study, patient approval and informed consent weren't requested by the ethic committee.</p>
    </sec>
  </body>
  <back>
    <ref-list>
      <ref id="ridm1842247220">
        <label>1.</label>
        <mixed-citation xlink:type="simple" publication-type="journal">
          <source>İskender Sayek Temel Cerrahi Cilt</source>
          <volume>2</volume>
          <fpage>1737</fpage>
          <lpage>1738</lpage>
        </mixed-citation>
      </ref>
      <ref id="ridm1842250388">
        <label>2.</label>
        <mixed-citation xlink:type="simple" publication-type="journal">
          <fpage>1343</fpage>
          <lpage>1344</lpage>
          <institution>Schwartz Cerrahinin İlkeleri</institution>
        </mixed-citation>
      </ref>
      <ref id="ridm1842315764">
        <label>3.</label>
        <mixed-citation xlink:type="simple" publication-type="book">
          <name>
            <surname>Murat</surname>
            <given-names>O</given-names>
          </name>
          <article-title>Acarsoy esansiyel Trombositoz. Duke Cancer İnstitute</article-title>
          <date>
            <year>2012</year>
          </date>
          <chapter-title>Oncology, USA 31ekim-03 kasım, Antalya XXXVIII Ulusal Hematoloji Kongresi</chapter-title>
          <institution>Department of Medicine, Duke University School of Medicine, Hematology-Medical</institution>
        </mixed-citation>
      </ref>
      <ref id="ridm1842258820">
        <label>4.</label>
        <mixed-citation xlink:type="simple" publication-type="journal">
          <name>
            <surname>Z</surname>
            <given-names>N Özdemir</given-names>
          </name>
          <name>
            <surname>Şahin</surname>
            <given-names>U</given-names>
          </name>
          <name>
            <surname>S</surname>
            <given-names>C Bozdağ</given-names>
          </name>
          <name>
            <surname>M</surname>
            <given-names>K Yüksel</given-names>
          </name>
          <name>
            <surname>S</surname>
            <given-names>K Toprak</given-names>
          </name>
          <name>
            <surname>Topçuoğlu</surname>
            <given-names>P</given-names>
          </name>
          <name>
            <surname>ÖZCAN</surname>
            <given-names>M</given-names>
          </name>
          <name>
            <surname>Arslan</surname>
            <given-names>Ö</given-names>
          </name>
          <name>
            <surname>Demirer</surname>
            <given-names>T</given-names>
          </name>
          <name>
            <surname>Beksaç</surname>
            <given-names>M</given-names>
          </name>
          <name>
            <surname>Gürman</surname>
            <given-names>G</given-names>
          </name>
          <name>
            <surname>İlhan</surname>
            <given-names>O</given-names>
          </name>
          <article-title>Trombositozlu olgularda terapotik trombosit aferezinin etkinliği. İlhan. Ankara Üniversitesi Tıp Mecmuası</article-title>
          <date>
            <year>2021</year>
          </date>
          <volume>74</volume>
          <fpage>3</fpage>
          <lpage>278</lpage>
        </mixed-citation>
      </ref>
      <ref id="ridm1842104676">
        <label>5.</label>
        <mixed-citation xlink:type="simple" publication-type="journal">
          <name>
            <surname>Berna</surname>
            <given-names/>
          </name>
          <article-title>Atabay İmmun (idiyopatik) trombositopenik purpura: Patofizyoloji, tanı ve tedavi. SSK Tepecik Hast Derg</article-title>
          <date>
            <year>2003</year>
          </date>
          <volume>13</volume>
          <issue>2</issue>
          <fpage>63</fpage>
          <lpage>74</lpage>
        </mixed-citation>
      </ref>
      <ref id="ridm1842110004">
        <label>6.</label>
        <mixed-citation xlink:type="simple" publication-type="journal">
          <name>
            <surname>Tekeli</surname>
            <given-names>Demet</given-names>
          </name>
          <article-title>Talasemi majör ve talasemi intermedier hastalarındaki fasiyal değişikliklerin üç boyutlu karşılaştırılması</article-title>
          <source>S</source>
          <volume>9</volume>
        </mixed-citation>
      </ref>
      <ref id="ridm1842107700">
        <label>7.</label>
        <mixed-citation xlink:type="simple" publication-type="journal">
          <name>
            <surname>Leonard</surname>
            <given-names>A</given-names>
          </name>
          <name>
            <surname>J</surname>
            <given-names>F Tisdale</given-names>
          </name>
          <name>
            <surname>Bonner</surname>
            <given-names>M</given-names>
          </name>
          <article-title>Gen therapy for hemoglobinopathies: beta thalassemia, sickle cell disease. Hematology/ oncology clinics of north America volum 36, issue 4</article-title>
          <date>
            <year>2022</year>
          </date>
          <fpage>769</fpage>
          <lpage>775</lpage>
        </mixed-citation>
      </ref>
      <ref id="ridm1842096068">
        <label>8.</label>
        <mixed-citation xlink:type="simple" publication-type="journal">
          <name>
            <surname>Almalı</surname>
            <given-names>N</given-names>
          </name>
          <name>
            <surname>Yılmaz</surname>
            <given-names>Ö</given-names>
          </name>
          <article-title>204 splenektomi olgusunun analizi, splenektomi endikasyonları değişiyor mu? Van tıp derg</article-title>
          <date>
            <year>2019</year>
          </date>
          <volume>26</volume>
          <issue>4</issue>
          <fpage>520</fpage>
          <lpage>525</lpage>
        </mixed-citation>
      </ref>
      <ref id="ridm1842093044">
        <label>9.</label>
        <mixed-citation xlink:type="simple" publication-type="journal">
          <name>
            <surname>Görkem</surname>
            <given-names>M</given-names>
          </name>
          <name>
            <surname>M</surname>
            <given-names>H Atay</given-names>
          </name>
          <name>
            <surname>Kelkitli</surname>
            <given-names>E</given-names>
          </name>
          <name>
            <surname>Büyükkaya</surname>
            <given-names>P</given-names>
          </name>
          <name>
            <surname>Özatlı</surname>
            <given-names>D</given-names>
          </name>
          <name>
            <surname>Güler</surname>
            <given-names>N</given-names>
          </name>
          <name>
            <surname>Turgut</surname>
            <given-names>M</given-names>
          </name>
          <article-title>Hematolojik hastalıklarda splenektomi; tek merkez deneyimi. Deneysel ve klinik tıp dergisi 29</article-title>
          <date>
            <year>2012</year>
          </date>
          <fpage>276</fpage>
          <lpage>279</lpage>
        </mixed-citation>
      </ref>
      <ref id="ridm1842084596">
        <label>10.</label>
        <mixed-citation xlink:type="simple" publication-type="journal">
          <name>
            <surname>Michael</surname>
            <given-names>Bouvet MD</given-names>
          </name>
          <name>
            <surname>MD</surname>
            <given-names>Gildy V Babiera</given-names>
          </name>
          <name>
            <surname>MD</surname>
            <given-names>Paula M Termuhlen</given-names>
          </name>
          <name>
            <surname>MD</surname>
            <given-names>Jeane P Hester</given-names>
          </name>
          <name>
            <surname>MD</surname>
            <given-names>Hagop M Kantarjian</given-names>
          </name>
          <name>
            <surname>MD</surname>
            <given-names>Raphael E Pollock</given-names>
          </name>
          <article-title>Splenectomy in the accelerated or blastic phase of chronic myelogenous leukemia: A single-institution, 25-year experience .SurgeryVolume 122</article-title>
          <date>
            <year>1997</year>
          </date>
          <source>Issue</source>
          <volume>1</volume>
          <fpage>Pages</fpage>
        </mixed-citation>
      </ref>
      <ref id="ridm1842083660">
        <label>11.</label>
        <mixed-citation xlink:type="simple" publication-type="journal">
          <name>
            <surname>R</surname>
            <given-names>A Mesa</given-names>
          </name>
          <name>
            <surname>M</surname>
            <given-names>A Elliott</given-names>
          </name>
          <name>
            <surname>Tefferi</surname>
            <given-names>A</given-names>
          </name>
          <article-title>Splenectomy in chronic myeloid leukemia and myelofibrosis with myeloid metaplasia Blood Review</article-title>
          <date>
            <year>2000</year>
          </date>
          <volume>14</volume>
          <issue>3</issue>
          <fpage>121</fpage>
          <lpage>9</lpage>
          <pub-id pub-id-type="doi">10.1054/blre.2000.0132</pub-id>
        </mixed-citation>
      </ref>
      <ref id="ridm1842079196">
        <label>12.</label>
        <mixed-citation xlink:type="simple" publication-type="journal">
          <name>
            <surname>A</surname>
            <given-names>J Hale</given-names>
          </name>
          <name>
            <surname>Depo</surname>
            <given-names>B</given-names>
          </name>
          <name>
            <surname>Khan</surname>
            <given-names>S</given-names>
          </name>
          <name>
            <surname>Whitman</surname>
            <given-names>J</given-names>
          </name>
          <name>
            <surname>Bullis</surname>
            <given-names>S</given-names>
          </name>
          <name>
            <surname>Singh</surname>
            <given-names>D</given-names>
          </name>
          <name>
            <surname>Peterson</surname>
            <given-names>K</given-names>
          </name>
          <name>
            <surname>Hyson</surname>
            <given-names>P</given-names>
          </name>
          <name>
            <surname>Catoe</surname>
            <given-names>L</given-names>
          </name>
          <name>
            <surname>B</surname>
            <given-names>J Tompkins</given-names>
          </name>
          <name>
            <surname>W</surname>
            <given-names>K Alston</given-names>
          </name>
          <name>
            <surname>Dejace</surname>
            <given-names>J</given-names>
          </name>
          <article-title>The impact of standardized infectious diseas consultation on postsplenectomy care and outcomes. Open forum infectious diseases</article-title>
          <date>
            <year>2022</year>
          </date>
          <volume>9</volume>
          <issue>8</issue>
          <fpage>380</fpage>
        </mixed-citation>
      </ref>
      <ref id="ridm1842069228">
        <label>13.</label>
        <mixed-citation xlink:type="simple" publication-type="journal">
          <name>
            <surname>D</surname>
            <given-names/>
          </name>
          <name>
            <surname>Fasano</surname>
            <given-names>A</given-names>
          </name>
          <name>
            <surname>Gelsormino</surname>
            <given-names>M</given-names>
          </name>
          <article-title>Laparascopic partial splenectomy using the harmonic scalpel for parenchymal transsection two case reports and review of the literature.Acta Biomed</article-title>
          <date>
            <year>2021</year>
          </date>
        </mixed-citation>
      </ref>
      <ref id="ridm1842066708">
        <label>14.</label>
        <mixed-citation xlink:type="simple" publication-type="journal">
          <name>
            <surname>Bian</surname>
            <given-names>A Zarzavadjian le</given-names>
          </name>
          <name>
            <surname>M</surname>
            <given-names>C Sarretti</given-names>
          </name>
          <name>
            <surname>Costi</surname>
            <given-names>R</given-names>
          </name>
          <name>
            <surname>N</surname>
            <given-names>E Arbi</given-names>
          </name>
          <name>
            <surname>C</surname>
            <given-names>S Madja</given-names>
          </name>
          <name>
            <surname>A</surname>
            <given-names/>
          </name>
          <article-title>Valverde.Laparascopic partial splenectomy with selective pediculer approach. Journal of visceral surgery</article-title>
          <date>
            <year>2017</year>
          </date>
          <volume>154</volume>
          <issue>1</issue>
          <fpage>63</fpage>
          <lpage>64</lpage>
        </mixed-citation>
      </ref>
      <ref id="ridm1842061812">
        <label>15.</label>
        <mixed-citation xlink:type="simple" publication-type="journal">
          <article-title>Türk Silahlı kuvvetleri Jandarma genel komutanlığı ve Sahil güvenlik komutanlığı Sağlık yönetmeliği. Resmi Gazete.11.11.2016.29885</article-title>
        </mixed-citation>
      </ref>
    </ref-list>
  </back>
</article>
