Protein kinase C (PKC) signalling is a cellular communication pathway built around a family of enzymes called protein kinases C, which transmit signals from the cell surface to internal targets by adding phosphate groups to specific proteins. The pathway is typically activated when extracellular signals trigger the …
Protein kinase C (PKC) signalling is a cellular communication pathway built around a family of enzymes called protein kinases C, which transmit signals from the cell surface to internal targets by adding phosphate groups to specific proteins. The pathway is typically activated when extracellular signals trigger the production of second messengers such as diacylglycerol and, for many PKC isoforms, an increase in intracellular calcium; these activate PKC enzymes, which then phosphorylate downstream proteins and thereby alter their activity. Through this mechanism, PKC signalling regulates a wide range of cellular processes, including cell growth, division, differentiation, gene expression, and programmed cell death, and it participates in immune responses and the function of many tissues. Because of its central regulatory role, dysregulation of PKC signalling has been implicated in diseases including cancer, cardiovascular disorders, and diabetes, making it an important subject for biomedical research and a target for drug development. Within Biotechnology and Biomedical Science, the study of such signalling pathways draws on molecular and proteomic methods to map how cells receive and process information. This page gathers peer-reviewed, open-access research relevant to cell signalling and molecular biomedical science.
6 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 6 articles above have been cited 315 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
A sample of recent works citing this journal's research on Protein Kinase C Signaling, linking to each citing work.