Negative-sense Rna Viruses
Negative-sense RNA viruses are a type of virus in which the genetic material is carried in the form of single-stranded RNA molecules that have an opposite polarity (or orientation) to the single-stranded messenger RNA molecules that are translated into proteins. Because of their opposite polarity, these viruses can't be read directly by the cell's protein-synthesis machinery. Instead, the virus must first produce a complementary positive-sense RNA molecule, which can be recognized by the host cell and translated into proteins. Negative-sense RNA viruses are important pathogens of humans, animals, and plants, and they cause a variety of illnesses, including the common cold, hepatitis C, smallpox, and rabies. Negative-sense RNA viruses are also used in research and have been developed as potential gene therapy vectors.
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