Proteoglycans

Proteoglycans are macromolecules found in the extracellular matrix of eukaryotic cells. They are comprised of a core protein to which polysaccharide chains (glycosaminoglycans), such as glycosaminoglycan, are covalently attached. Proteoglycans play a vital role in tissue development and organization, as they are involved in the formation and maintenance of cells, tissues and organs. They are important for many biological processes, including cell recognition, cell adhesion, binding of molecules and growth factor signaling. Furthermore, proteoglycans have been found to have therapeutic applications in a variety of diseases, including cancer, neurodegenerative disorders and inflammatory conditions.