Journal of Hematology and Oncology Research

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Hematology and Oncology Research-CML-Yi Shan

United States

University of Massachusetts Medical School.

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Yi Shan


364 Plantation st,
Worcester, MA 01605.

Research Interests:

CML, AML, BALL, MPD, Leukemia stem cell, Cancer biology, Cancer gene therapy.



  1. LAPTM4B: a novel cancer-associated gene motivates multidrug resistance through efflux and activating PI3K/AKT signaling.
  2. A therapeutically targetable mechanism of BCR-ABL–independent imatinib resistance in chronic myeloid leukemia.
  3. A tumor suppressor function of the Msr1 gene in leukemia stem cells of chronic myeloid leukemia.
  4. Overexpression of LAPTM4B-35 attenuates epirubucin-induced apoptosis of gallbladder carcinoma GBC-SD cells.
  5. Arachidonate 15-lipoxygenase is required for chronic myeloid leukemia stem cell survival.
  6. Functional ramifications for the loss of P-selectin expression on hematopoietic and leukemic stem cells.
  7. Upregulation of LAPTM4B‐35 Promotes Malignant Transformation and Tumorigenesis in L02 Human Liver Cell Line.
  8. LSK Derived LSK–Cells Have a High Apoptotic Rate Related to Survival Regulation of Hematopoietic and Leukemic Stem Cells.
  9. Targeting a novel cancer-driving protein (LAPTM4B-35) by a small molecule (ETS) to inhibit cancer growth and metastasis.
  10. Targeting chronic myeloid leukemia stem cells with the hypoxia-inducible factor inhibitor acriflavine.