Open Access Pub · ISSN 2578-8590
Peer-reviewed research on physiological function — how it is produced, how it is regulated, and how it changes — at every level of biological organization, from transport across a single membrane to the response of an intact organism.
Open access under CC BY 4.0 · Aims and Scope · Current issue · Archive · Submit a manuscript
Research in the journal
Each study below is introduced in the editors’ words. The full record, including editorials and shorter contributions, is in the Archive.
Research Article
Reduced Tissue Oxygenation and Altered Valsalva Hemodynamics in Young Adults with Type 1 Diabetes
Maria Bitsch Poulsen, Peter Oketa-Onyut Julu, Memon Schah, Mussadiq Shah, Christina Brock
A cross-sectional comparison of fifteen young adults with type 1 diabetes and fifteen age-matched controls, assessed with standardized cardiovascular autonomic reflex tests alongside continuous beat-to-beat blood pressure and transcutaneous tissue gas recording. Reflex ratios were preserved in both groups, while baseline tissue oxygenation was lower in the diabetes group and the blood-pressure response to the Valsalva maneuver differed across its phases. The authors read the two observations together as possible early signs of dysautonomia and state that longitudinal validation is required.
Research Article
Francesco Crespi
Concurrent voltammetric and electrophysiological recording in the substantia nigra, used to follow how nociceptin/orphanin FQ affects dopamine and then serotonin activity. The work is an example of mechanism established at the level of the neural circuit rather than inferred from behavior.
In Brief
Swimming Critical Velocity Physiological Meaning is Affected by Testing Distances
Ricardo J. Fernandes
Swimming performance rests on energy expenditure, propulsive efficiency and hydrodynamic drag, and the laboratory measures that resolve them are invasive, time-consuming and costly. Critical velocity offers a field alternative derived from swimming performance itself. This contribution examines how the testing distances chosen for that determination change what the resulting velocity means physiologically.
Research Article
Diurnal Variation in the Core Interthreshold Zone in Women and its Sex Difference
Naoshi Kakitsuba, Igor B. Mekjavic
A study of the core interthreshold zone in women and how it varies across the day, with the sex difference reported alongside. Thermoregulatory control is measured directly rather than inferred from surface temperature.
Research Article
Substrate Stiffness Influences the Time Dependence of CTGF Protein Expression in Müller Cells
Joshua T Davis, William J Foster
An examination of how substrate stiffness influences the time course of CTGF protein expression in Müller cells, linking a mechanical property of the cellular environment to a measurable change in protein expression.
Where to start
Transport, excitability, signaling and cellular energetics, where the physiological consequence is made explicit.
Perfusion, gas exchange and the local conditions under which tissue performs work.
Function within a system, and the reflex, humoral and autonomic loops that couple one system to another.
Whole-body responses to exercise, environment, development and disease, in human and comparative work, and the methods that measure them.
The Aims and Scope page sets out the remit in full. The published record illustrates it; it does not set its boundary.
The current issue is Volume 2, Issue 3, 2019–2026. Read it.
24 editors currently serve on the Editorial Board.
Editorial handling
All submissions undergo initial editorial screening. Manuscripts that meet the journal’s scope and minimum requirements proceed to independent peer review. Single-blind by default; double-blind review is available on request. Manuscripts that proceed to external peer review are normally evaluated by at least two independent subject-matter experts.
Editorial decisions are based on scope, scientific quality, methodological rigor, ethical compliance, reporting quality, and relevance to the journal.
Editorial decisions are independent of fees, services, membership, and editorial or reviewer roles.
Instructions for Authors · Article Processing Charges · Editorial Policies
International Physiology Journal
ISSN 2578-8590 · Published by Open Access Pub · Open access under a Creative Commons Attribution 4.0 International (CC BY 4.0) license · Article DOIs use the publisher prefix 10.14302.