Journal of Peptides

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Journal of Peptides

A peer-reviewed open access journal for work in which the peptide is the scientific question — how it is designed and made, what shape it takes, what it does, and what can be built from it.

Contributions may be chemical, structural, analytical, biological, computational, pharmacological or translational. Foundational and applied studies are read on the same terms.

Skeletal drawing of a head-to-tail cyclic peptide An original schematic, cropped by its frame: nine residues closed into a macrocycle, showing the repeating amide backbone, the carbonyl oxygens and the alpha-carbon side-chain positions.
Head-to-tail macrocycle, nine residues — original schematic of the repeating amide backbone closed into a ring.

Most recent in the journal

Review · August 22, 2026 Volume 1, Issue 2 · pages 1–13

Cyclic Peptides: Prominent Next Generation Targeted Therapies

Manjula Reddy Pallerla, Bhairaiah Mara, Ramesh babu Konda, Ataharoddin Khaja — Peptide R&D, Matrix Pharmacorp Pvt. Ltd., Hyderabad, India

Closing a peptide into a ring changes what the molecule can reach. This review sets out how macrocyclic peptides are built and selected — phage display, genetic code expansion with noncanonical amino acids, and a range of cyclization chemistries — and what constraining the backbone yields: target affinity, metabolic stability and pharmacokinetic behavior that sit between small molecules and biologics.

It surveys the pharmacological activities reported for the class and describes where candidates currently stand in development, then treats the same molecules as laboratory reagents rather than only as candidates: selective probes for modulating target proteins, and high-affinity ligands for biomolecular imaging.

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Also in the published record

Four more, entered by what each contributes

The journal’s record is short and its range is real: two synthesis methods, one aggregation study and one bioactivity screen. They are listed by the kind of contribution they make rather than by date.

  1. Synthesis method

    Peptide Synthesis in Aqueous Solution With a Reusable Solid Phase

    Yong Ma · Short Communication · April 30, 2024 · Volume 1, Issue 1, pages 1–11

  2. Protecting-group chemistry

    Protection Side Chain of Lysine by Host-Affinity Molecules during Solid Phase Peptide Synthesis in Aqueous Phase

    Yong Ma · Short Communication · September 19, 2024 · Volume 1, Issue 1, pages 34–42

  3. Aggregation and structure

    Novel Methods for Inhibiting Amyloidogenesis in the Presence of Peptides to Block Hydrophobic Interactions

    Masatoshi Saiki, Ikumi Shibatate · Rapid Communication · July 30, 2024 · Volume 1, Issue 1, pages 27–33

  4. Bioactivity

    Biological Activities of Four Synthetized Peptides

    Olivier Ndogo Eteme, Ernestine Nkwengoua Zondegoumba, Eteme Enama Serge, Wendell Queiroz Leite, Mariane de Freitas Genari Severino, Apollinaire Tsopmo · Research Article · July 28, 2024 · Volume 1, Issue 1, pages 12–26

Browse the archive →

Editorial responsibility

How manuscripts are handled

Editorial decisions are independent of fees, services, membership and editorial or reviewing roles.

The board is listed in full on the Editorial Board page.

All submissions undergo initial editorial screening. Manuscripts that meet the journal’s scope and minimum requirements proceed to independent peer review. Single-blind by default; double-blind review is available on request. Manuscripts that proceed to external peer review are normally evaluated by at least two independent subject-matter experts.

Editorial decisions are based on scope, scientific quality, methodological rigor, ethical compliance, reporting quality, and relevance to the journal. Evidence is weighed against the claims a manuscript actually makes, which is set out on the Aims and Scope page.

The journal is open access. Articles are published under the license stated on each article, and an article processing charge applies to accepted manuscripts; the current terms are on the Article Processing Charges page.

Submitting to Journal of Peptides

  1. Primary route: ManuscriptZone
  2. Alternative route: Simple manuscript submission form
  3. Assisted route: [email protected]

Authors must use only one submission route for the same manuscript. Accepted formats are Research Article, Review Article (including systematic reviews), Methods Article, Data/Resource Article, and Short Communication. Editorial and Perspective/Commentary are by invitation only.

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