Molecular Replacement
Molecular replacement (MR) is a widely used method in X-ray crystallography for solving the structure of a protein or other biological molecules by replacing the unknown model with an already known one, such as a homologous structure from previously determined structures. This can be used to determine the unknown structure at a resolution greater than the limit of crystallography techniques, or in cases where there is no existing structure. In addition, it can be used to calculate atomic-level motion in proteins and to design new drugs. Molecular replacement helps to understand the molecular basis of diseases, investigate the mechanisms of drug discovery, and develop novel molecular structures in a cost-effective manner.
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