Retinoic Acid Signaling Cascade
Retinoic acid (RA) signaling cascade is a process by which RA affects gene expression through a cascade of events in the cell nucleus. It is an important part of the developmental process throughout multicellular organisms. RA signaling is critical for embryonic development, controlling the timing and number of cell divisions, and promoting or suppressing the differentiation of cells into particular tissues. In post-embryonic development, it is essential for the maintenance of proper cell-to-cell and cell-to-matrix communication during tissue renewal and remodeling. In adult organisms, RA is involved in important physiological processes such as inflammation, wound healing, tissue toxicity, and tumor formation. The RA signaling cascade is also important for the management of rare genetic disorders including retinitis pigmentosa, and is being researched as a potential treatment for a variety of diseases.
← Journal of New Developments in Molecular Biology