Journal of Skeletal Muscle

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Skeletal Muscle-excitation-contraction coupling-Gerhard Meissner

United States

University of North Carolina, 
Dept. Biochemistry and Biophysics.

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Gerhard Meissner


Dept. Biochemistry and Biophysics,
University of North Carolina,
Chapel Hill, NC 27599-7260.

Research Interests:

  • excitation-contraction coupling
  • ryanodine receptor
  • sarcoplasmic reticulum


  1. Mei Y, Xu L, Mowrey DD, Mendez Giraldez R, Wang Y, Pasek DA, Dokholyan NV, Meissner G.  Channel gating dependence on pore lining helix glycine residues in skeletal muscle ryanodine receptor.  J Biol Chem 290, 17535-17545, 2015
  2. Mei Y, Xu L, Kramer HF, Tomberlin GH, Townsend C, Meissner G. Stabilization of the skeletal muscle ryanodine receptor ion channel-FKBP12 complex by the benzothiazepine derivative S107. PLoS One 8:e54208, 2013
  3. Ramachandran S, Chakraborty A, Xu  L, Mei Y, Samso M, Dokholyan NV, Meissner G. Structural determinants of skeletal muscle ryanodine receptor gating. J Biol Chem 288:6154-6165, 2013
  4. Meissner G, Pasek DA, Yamaguchi N, Ramachandran S, Dokholyan NV, Tripathy A. Thermodynamics of  calmodulin binding to cardiac and skeletal muscle ryanodine receptor ion channels. Proteins 74:207-211, 2009
  5. Ghassemi F, Vukcevic M,  Xu L, Zhou H, Meissner G, Muntoni F, Jungbluth H, Zorzato F,Treves S. A recessive ryanodine receptor 1 mutation in a CCD patient increases channel activity. Cell Calcium 45:192-197, 2009 
  6. Xu L, Wang Y, Yamaguchi N, Pasek DA, Meissner G. Single channel properties of heterotetrameric mutant RyR1 ion channels linked to core myopathies. J Biol Chem, 283:6321-6329, 2008 
  7. Xu L, Wang Y, Gillespie D, Meissner G. Two rings of negative charges in the cytosolic vestibule of type-1 ryanodine receptor modulate ion fluxes. Biophys J 90:443-453, 2006
  8. Petrotchenko EV, Pasek D, Elms P, Dokholyan NV, Meissner G, Borchers CH. Combining fluorescence detection and mass spectrometric analysis for comprehensive and quantitative analysis of redox-sensitive cysteines in native membrane proteins. Anal Chem 78, 7959-7966, 2006 
  9. Sun J, Xu L, Eu JP, Stamler JS, Meissner G: Nitric oxide, NOC-12 and S-nitrosoglutathione modulate the skeletal muscle calcium release channel/ryanodine receptor by different mechanisms: An allosteric function for O2 in S-nitrosylation of the channel. J Biol Chem 278:8184-8189, 2003
  10. Yamaguchi N, Xin C, Meissner G: Identification of apocalmodulin and Ca2+-calmodulin regulatory domain in skeletal muscle Ca2+ release channel, ryanodine receptor. J Biol Chem 276:22579-22585, 2001
  11. Gao L, Balshaw D, Xu L, Tripathy A, Xin C, Meissner G: Evidence for a role of the lumenal M3-M4 loop in skeletal muscle Ca2+ release channel (ryanodine receptor) activity and conductance. Biophys J 79:828-840, 2000  
  12. Eu JP, Sun J, Xu L, Stamler JS, Meissner G: The skeletal muscle calcium release channel: coupled O2 sensor and NO signaling functions. Cell 102:499-509, 2000