Research Topic · Peer-Reviewed

Platelets

Platelets, or thrombocytes, are small anucleate cell fragments derived from megakaryocytes in the bone marrow that circulate in blood and are essential to haemostasis. On vascular injury they adhere to exposed subendothelial collagen via von Willebrand factor, undergo activation and shape change, secrete the content…

Curated from this journal's research 📚 12 peer-reviewed articles cited Cited 38× across the literature 🗓 Reviewed June 2026

Overview

Platelets, or thrombocytes, are small anucleate cell fragments derived from megakaryocytes in the bone marrow that circulate in blood and are essential to haemostasis. On vascular injury they adhere to exposed subendothelial collagen via von Willebrand factor, undergo activation and shape change, secrete the contents of their granules, and aggregate through fibrinogen bridging of glycoprotein IIb/IIIa receptors to form the primary haemostatic plug, while their surface provides a platform for coagulation-factor assembly. Beyond clotting, platelets contribute to inflammation, wound healing, and angiogenesis through release of growth factors, and their dysregulation underlies both bleeding disorders and pathological thrombosis. The peer-reviewed work collected here engages these roles within thrombosis and its treatment: glucose and apoptosis in stored platelets, laboratory diagnosis and management of immune thrombocytopenia, acute normovolaemic haemodilution in cardiac surgery, megakaryocytes in arthritic joints, hypercoagulability in acute leukaemia, platelet-rich fibrin in bone-defect repair, fibrin-network changes in COVID-19 microthrombi, and inherited mutations in coagulation factors and regulatory proteins. Across these studies platelets appear in the contexts of transfusion science, thrombocytopenia, surgical blood management, and the interplay of platelets with coagulation and fibrin. The collection emphasizes platelet function, storage, and pathology, and their central position in haemostasis, thrombosis, and the regulation of bleeding.

Research published in this journal

12 peer-reviewed articles, ranked by relevance. Each links to its DOI.

How this research is being cited

The 12 articles above have been cited 38 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Platelets, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in Thrombosis and treatments.

Journal editorial board
Hsueh-Wen Chang · Taiwan Ioanna Koniari · Greece

This page summarises published research for orientation; it is not medical or professional advice.