Journal of Ophthalmic Science

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Ophthalmic Science-epigenetic regulation of cell differentiation
-Guo-Zhang Zhu

united states

Marshall University


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Guo-Zhang Zhu


Department of Biological Sciences
Marshall University
Huntington, WV 25705

Research Interests:

epigenetic regulation of cell differentiation



  1. Yan Liu, Yue Huang, Jun Fan, Guo-Zhang Zhu. PITX2 associates with PTIP-containing histone H3 lysine 4 methyltransferase complex. Biochem Biophys Res Commun. 2014, 444(4):634-637.
  2. Yan Liu, Yue Huang, Guo-Zhang Zhu. Cyclin A1 is a transcriptional target of PITX2 and overexpressed in papillary thyroid carcinoma. Mol Cell Biochem. 2013, 384:221–227.
  3. Yue Huang, Celine J. Guigon, Jun Fan, Sheue-yann Cheng, and Guo-Zhang Zhu. Pituitary Homeobox 2 (PITX2) Promotes Thyroid Carcinogenesis by Activation of Cyclin D2. Cell Cycle. 2010, 9(7): 1333-1341.
  4. Jun Fan, Guo-Zhang Zhu, and Richard M. Niles. Expression and Function of CD9 in Melanoma Cells. Mol Carcinog. 2010, 49(1):85-93.
  5. Guo-Zhang Zhu, Surabhi Gupta, Diana Gold Myles, Paul Primakoff. Testase 1 (ADAM 24) a sperm surface metalloprotease is required for normal fertility in mice. Mol Reprod Dev. 2009, 76(11): 1106-1114. 
  6. Yue Huang, Kan Huang, Goran Boskovic, Yulia Dementieva, James Denvir, Donald A. Primerano, Guo-Zhang Zhu. Proteomic and genomic analysis of PITX2 interacting and regulating networks. FEBS Lett. 2009, 583(4): 638-42.
  7. Zhigang Jin, Jianli Shi, Amit Saraf, Wenyan Mei, Guo-Zhang Zhu, Stefan Strack, Jing Yang. The 48 kDa alternative translation isoform of PP2A:B56epsilon is required for Wnt signaling during midbrain-hindbrain boundary formation. J Biol Chem. 2009, 284(11): 7190-200.
  8. Jing Yang, Chin Yee Chan, Bo Jiang Xueyuan Yu, Guo-Zhang Zhu, Yiping Chen, John Barnard, Wenyan Mei. hnRNP I inhibits Notch signaling and regulates intestinal epithelial homeostasis in zebrafish. PLoS Genetics. 2009 Feb; 5(2):e1000363.
  9. Yue Huang, Jun Fan, Jing Yang, Guo-Zhang Zhu. Characterization of GPR56 protein and its suppressed expression in human pancreatic cancer cells. Molecular and Cellular Biochemistry. 2008, 308(1-2):133-139.
  10. Jun Fan, Hiroto Akabane, Xuehai Zheng, Xuan Zhou, Li Zhang, Qiang Liu, Yong-Lian Zhang, Jing Yang, Guo-Zhang Zhu. Male germ cell specific expression of a novel Patched-domain containing gene Ptchd3. Biochemical and Biophysical Research Communications. 2007, 363:757- 761.