Sickle Cell Disease
Sickle cell disease is a genetic disorder caused by a mutation in the gene which produces the oxygen-carrying protein in red blood cells, hemoglobin. The mutation causes hemoglobin molecules to form abnormally shaped red blood cells which become rigid and sticky, and get stuck in blood vessels. This blockage in the blood vessels can lead to anemia, pain, organ damage, and other complications. It is especially common among those of African and Mediterranean descent, and is a major public health concern in many parts of the world. Sickle cell disease requires lifelong management to reduce the risk of developing life-threatening complications, including through medicines, lifestyle changes, and regular monitoring of blood counts.
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