Journal of Antioxidant Activity

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Antioxidant Activity-Antioxidant research in cardiac and vascular remodeling-Sudhiranjan Gupta, Ph.D.

United States

Texas A&M University.



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Sudhiranjan Gupta, Ph.D.


1901 South 1st Street, Building 205,
Temple, Texas 76504,.

Research Interests:

  • Antioxidant research in cardiac and vascular remodeling
  • miRNA modulation in cardiac remodeling
  • Pulmonary hypertension



  1. Li L, Bound K, Chatterjee, K, Gupta S. MicroRNA-130a, a potential for antifibrotic target in cardiac fibrosis. J Am Heart Assoc 2017 (in press).
  2. Li L, Kim IK, Chiasson V, Chatterjee P, Gupta S. NF-kB mediated miR-130a modulation in lung microvascular cell: implication in pulmonary hypertension. Exp Cell Res. 2017;359(1):235-242. doi: 10.1016/j.yexcr.2017.07.024. PMID: 28755990
  3. Li L, Wei C, Kim IK, Janssen-Heininger Y, Gupta S. Inhibition of nuclear factor-kB in the lungs prevents monocrotaline-induced pulmonary hypertension in mice. Hypertension. 2014 Jun;63(6):1260-9. doi: 10.1161/HYPERTENSIONAHA.114.03220. PMID: 24614212
  4. Wei C, Kim IK, Kumar S, Jayasinghe S, Hong N, Castoldi G, Catalucci D, Jones WK, Gupta S. NF-kB mediated miR-26a regulation in cardiac fibrosis. J Cell Physiol. 2013 Jul;228(7):1433- 42. doi: 10.1002/jcp.24296. PMID: 23254997
  5. Wei C, Henderson H, Spradley C, Li L, Kim IK, Kumar S, Hong N, Arroliga AC, Gupta S. Circulating miRNAs as potential marker for pulmonary hypertension. PLoS One. 2013 May;8(5):e64396. doi: 10.1371/journal.pone.0064396. PMID: 23717609; PMCID: PMC3662705
  6. Kumar S, Wei C, Thomas CM, Kim IK, Seqqat R, Kumar R, Baker KM, Jones WK, Gupta S. Cardiac-specific genetic inhibition of nuclear factor-kB prevents right ventricular hypertrophy induced by monocrotaline. Am J Physiol Heart Circ Physiol. 2012 Apr 15;302(8):H1655–66. doi: 10.1152/ajpheart.00756.2011. PMID: 22245771
  7. Kumar S, Seqqat R, Chigurupati S, Kumar R, Baker KM, Young D, Sen S, Gupta S. Inhibition of nuclear factor kB regresses cardiac hypertrophy by modulating the expression of extracellular matrix and adhesion molecules. Free Radic Biol Med. 2011 Jan 1;50(1):206-15. doi: 10.1016/j.freeradbiomed.2010.10.711. PMID 21047552
  8. Fukuda K, Gupta S, Chen K, Wu C, Qin J. The pseudoactive site of ILK is essential for its binding to alpha-Parvin and localization to focal adhesions. Mol Cell. 2009 Dec 11;36(5):819-30. doi: 10.1016/j.molcel.2009.11.028. PMID: 20005845; PMCID: PMC2796127
  9. Gupta S, Young D, Maitra RK, Gupta A, Popovic ZB, Yong SL, Mahajan A, Wang Q, Sen S. Prevention of cardiac hypertrophy and heart failure by silencing of NF-kappaB. J Mol Biol. 2008 Jan 18;375(3):637-49. doi: 10.1016/j.jmb.2007.10.006. PMID: 18037434; PMCID: PMC2277468
  10. Gupta S, Purcell NH, Lin A, Sen S. Activation of nuclear factor-kappaB is necessary for myotrophin-induced cardiac hypertrophy. J Cell Biol. 2002 Dec 23;159(6):1019-28. doi: 10.1083/jcb.200207149. PMID: 12486112; PMCID: PMC2173971